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A re-assessment of the health risks of chlorophenoxy herbicides based on an endocrine toxicity model

Pranulis, Stephen B. author ;Jones, Carol A. thesis advisor


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  • Title:
    A re-assessment of the health risks of chlorophenoxy herbicides based on an endocrine toxicity model
  • Author/Creator: Pranulis, Stephen B. author
  • Jones, Carol A. thesis advisor; Central Connecticut State University. Department of Chemistry.
  • Creation Date: 1995
  • Language: English
  • Physical Description: [1], ii, 42 leaves : illustrations ; 29 cm.; paper 29 cm. ink typescript.
  • Bibliography: Includes bibliographical references (leaves 37-42).
  • Subjects: Herbicides -- Toxicology; Xenobiotics -- Psysiological effect; Chemical carcinogenesis
  • Description: Chlorophenoxy herbicides were among the first synthetic chlorinated organic compounds used in bulk by the agriculture industry, and they have remained a widespread source of human exposure to synthetic toxicants to this day. An increase in the incidence of certain malignancies corresponds with the inception of the use of chlorophenoxy herbicides, and there is strong evidence of a causal relationship. The level of risk of acquiring various cancers has been calculated for some occupationally exposed cohorts, but a dose-response relationship for low level or long term exposure to chlorophenoxy compounds has not been established. An examination was made of the evidence from epidemiological cohort studies and from laboratory studies, and this data was used to construct a model of chlorophenoxy toxicity. The model suggests that the critical dosage for certain types of toxicant induced DNA damage consists of relatively low level, narrow, dose-response windows that bear similarity to endocrine or immune system control functions. Dose-response effects for this type of exposure are distinctly non-linear, and they will not be successfully predicted by high level exposure in laboratory animals. The model also implicates chlorophenoxy compounds in the etiology of diseases through their ability to cause genetic damage and to damage the body's system for toxicant disposal. This type of damage increases the probability that an exposed individual will suffer damage from a wide range of co-toxicants such as petroleum fuels and solvents, and is a likely factor in the etiology of non-Hodgkin's lymphoma. Methods for testing this model are proposed.
  • Notes: Includes bibliographical references (leaves 37-42).
  • Degree Granted: M.S. Central Connecticut State University 1995
  • OCLC Number: 36134610