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Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia

Bacher, Ulrike ; Haferlach, Torsten ; Schnittger, Susanne ; Weiss, Tamara ; Burkhard, Oswald ; Bechtel, Britta ; Kern, Wolfgang ; Haferlach, Claudia

Cancer Genetics and Cytogenetics, 2010, Vol.200(2), pp.170-174 [Peer Reviewed Journal]

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  • Title:
    Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia
  • Author/Creator: Bacher, Ulrike ; Haferlach, Torsten ; Schnittger, Susanne ; Weiss, Tamara ; Burkhard, Oswald ; Bechtel, Britta ; Kern, Wolfgang ; Haferlach, Claudia
  • Language: English
  • Subjects: Medicine ; Biology
  • Is Part Of: Cancer Genetics and Cytogenetics, 2010, Vol.200(2), pp.170-174
  • Description: Reciprocal IGH/14q32 translocations are detectable in 55–70% of patients with plasma cell myeloma; e.g., the adverse t(4;14)(p16;q32) fusing the IGH and FGFR3 genes (immunoglobulin heavy chain/fibroblast growth factor receptor 3). In a minority of patients with B-lineage chronic lymphocytic leukemia (CLL), reciprocal IGH/14q32 translocations have been reported as well. We describe the occurrence of a t(4;14)(p16;q32) in two lymphoma patients showing the immunophenotype of B-CLL, which, to our knowledge, is the first report on such an association. The first patient, a 72-year-old female, showed mature lymphocyte infiltration of the bone marrow and marked splenomegaly. Immunophenotyping revealed aberrant CD5 expression and light-chain lambda restriction on mature B-lymphocytes corresponding to a B-CLL. Interphase fluorescence in situ hybridization (FISH) plus chromosome banding revealed a t(4;14)(p16;q32) in addition to an unbalanced der(16)t(8;16)(q23;p13) and a...
  • Identifier: ISSN: 0165-4608 ; E-ISSN: 1873-4456 ; DOI: 10.1016/j.cancergencyto.2010.03.009