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Biological and clinical characterization of recurrent 14q deletions in CLL and other mature B-cell neoplasms

Reindl, Lena ; Bacher, Ulrike ; Dicker, Frank ; Weiss, Tamara ; Kern, Wolfgang ; Schnittger, Susanne ; Haferlach, Torsten ; Haferlach, Claudia ;Peer, Hal (Editor)

British Journal of Haematology, 22 July 2010, Vol.151(1), p.25 [Peer Reviewed Journal]

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  • Title:
    Biological and clinical characterization of recurrent 14q deletions in CLL and other mature B-cell neoplasms
  • Author/Creator: Reindl, Lena ; Bacher, Ulrike ; Dicker, Frank ; Weiss, Tamara ; Kern, Wolfgang ; Schnittger, Susanne ; Haferlach, Torsten ; Haferlach, Claudia
  • Peer, Hal (Editor)
  • Language: English
  • Subjects: Medicine ; Medicine
  • Is Part Of: British Journal of Haematology, 22 July 2010, Vol.151(1), p.25
  • Description: 14q-deletions were recurrently described in mature B-cell neoplasms, but not yet characterized in a larger cohort. With chromosome banding analysis, we identified 47 del(14q) cases in 3054 mature B-cell neoplasms (1.5%) (frequencies in CLL: 1.9%; CLL/PL: 9.0%; others: 0.2%). Interphase FISH was performed with probes for 14q22.1, 14q24.1, 14q32.33, and IgH (14q32.3). The del(14q) had heteregeneous size but showed a breakpoint cluster at the centromeric site in 14q24.1 (62% of cases). At the telomeric side, the most frequent breakpoint was within the IgH locus (14q32.3) between IgH3'-flanking and IgVH probes (45%). In 16 cases (34%), breakpoints occurred within 14q24.1 and 14q32.3. 81% of del(14q) cases showed 1-3 additional cytogenetic alterations (in 45%, +12), and 56% were IgVH-unmutated. In all cases (16/16) with breakpoints in 14q24.1 and 14q32.3, a B-CLL immunophenotype was found. Clinical follow-up in 32 del(14q) patients was compared to 383 CLL and CLL/PL patients without...
  • Identifier: ISSN: 0007-1048 ; E-ISSN: 1365-2141 ; DOI: 10.1111/j.1365-2141.2010.08299.x