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The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes

Cohen, Allison L ; Wenger, Julia B ; James-Todd, Tamarra ; Lamparello, Brooke M ; Halprin, Elizabeth ; Serdy, Shanti ; Fan, Shuling ; Horowitz, Gary L ; Lim, Kee-Hak ; Rana, Sarosh ; Takoudes, Tamara C ; Wyckoff, Jennifer A ; Thadhani, Ravi ; Karumanchi, S. Ananth ; Brown, Florence M

Hypertension in Pregnancy, 01 February 2014, Vol.33(1), pp.81-92 [Peer Reviewed Journal]

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  • Title:
    The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes
  • Author/Creator: Cohen, Allison L ; Wenger, Julia B ; James-Todd, Tamarra ; Lamparello, Brooke M ; Halprin, Elizabeth ; Serdy, Shanti ; Fan, Shuling ; Horowitz, Gary L ; Lim, Kee-Hak ; Rana, Sarosh ; Takoudes, Tamara C ; Wyckoff, Jennifer A ; Thadhani, Ravi ; Karumanchi, S. Ananth ; Brown, Florence M
  • Language: English
  • Subjects: Angiogenesis ; Diabetes ; Hba1c ; Plgf ; Preeclampsia ; Sflt1 ; Medicine
  • Is Part Of: Hypertension in Pregnancy, 01 February 2014, Vol.33(1), pp.81-92
  • Description: Objective: To assess whether glycemic control, soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF) were associated with the development of preeclampsia (PE) or gestational hypertension (GHTN) in women with preexisting diabetes. Methods: Maternal circulating angiogenic factors (sFlt1 and PlGF) measured on automated platform were studied at four time points during pregnancy in women with diabetes (N = 159) and reported as multiples of the median (MOM) of sFlt1/PlGF ratio (median, 25th-75th percentile) noted in non-diabetic non-hypertensive control pregnant population (N = 139). Diagnosis of PE or GHTN was determined by review of de-identified clinical data. Results: PE developed in 12% (N = 19) and GHTN developed in 23% (N = 37) of the women with diabetes. Among diabetic women without PE or GHTN, median sFlt1/PlGF levels at 35-40 weeks was threefold higher than in non-diabetic controls [MOM 3.21(1.19-7.24), p = 0.0001]. Diabetic women who subsequently developed...
  • Identifier: ISSN: 1064-1955 ; E-ISSN: 1525-6065 ; DOI: 10.3109/10641955.2013.837175