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Lupeol Is One of Active Components in the Extract of Chrysanthemum indicum Linne That Inhibits LMP1-Induced NF-κB Activation (NF-kB Inhibition by the Subfraction of CIE)

Kang, Se Chan ; Lim, Sue Yeon ; Song, Yoon-Jae ;Liu, Xuefeng (Editor)

2013, Vol.8(11), p.e82688 [Peer Reviewed Journal]

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  • Title:
    Lupeol Is One of Active Components in the Extract of Chrysanthemum indicum Linne That Inhibits LMP1-Induced NF-κB Activation (NF-kB Inhibition by the Subfraction of CIE)
  • Author/Creator: Kang, Se Chan ; Lim, Sue Yeon ; Song, Yoon-Jae
  • Liu, Xuefeng (Editor)
  • Language: English
  • Subjects: Research Article
  • Is Part Of: 2013, Vol.8(11), p.e82688
  • Description: We have previously reported that seventy percent ethanol extract of Chrysanthemum indicum Linne (CIE) strongly reduces Epstein-Barr virus (EBV)-transformed lymphoblastoid cell line (LCL) survival by inhibiting virus-encoded latent infection membrane protein 1 (LMP1)-induced NF-κB activation. To identify an active compound(s) in CIE that inhibits LMP1-induced NF-κB activation, activity-guided fractionation was employed. The CH 2 Cl 2 fraction of CIE strongly reduced LMP1-induced NF-κB activation and LCL viability with relatively low cytotoxic effects on primary human foreskin fibroblast (HFF), HeLa or Burkitt’s lymphoma (BL41) cells. Furthermore, lupeol, a pentacyclic triterpene, was identified in the CH 2 Cl 2 fraction of CIE to attenuate LMP1-induced NF-κB activation and LCL viability. This study demonstrates that lupeol is one of active compounds in the CH 2 Cl 2 fraction of CIE that inhibits LMP1-induced NF-κB activation and reduces NF-κB-dependent LCL viability.
  • Identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0082688