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Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality

Eero Lindholm ; Olle Melander ; Peter Almgren ; Göran Berglund ; Carl-David Agardh ; Leif Groop ; Marju Orho-Melander

PLoS ONE, 01 January 2006, Vol.1, p.e64 [Peer Reviewed Journal]

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  • Title:
    Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality
  • Author/Creator: Eero Lindholm ; Olle Melander ; Peter Almgren ; Göran Berglund ; Carl-David Agardh ; Leif Groop ; Marju Orho-Melander
  • Language: English
  • Subjects: Sciences (General)
  • Is Part Of: PLoS ONE, 01 January 2006, Vol.1, p.e64
  • Description: BACKGROUND: Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI).AIM: To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality.MATERIALS AND METHODS: Using an allelic discrimination method we genotyped 11,064 individuals from three study populations: 1) 4,432 individuals from the Botnia type 2 diabetes (T2D) study, 2) 1,222 patients with MI and 2,345 control subjects participating in the Malmö Diet and Cancer study and comprising an MI case-control sample, and 3) 3,065 T2D patients from the Local Swedish Diabetes registry.RESULTS: No association between the -168A-->G polymorphism in MHC2TA and MI was observed. However, in the Botnia cohort the AG/GG genotypes were associated with cardiovascular mortality after MI (1.78 [1.09-2.92], p = 0.02). In addition, the AG/GG genotypes were more common in subjects with MetS (40.1% vs. 36.9%, p = 0.03) and in non-diabetic subjects with microalbuminuria (45.4% vs. 36.5%, p = 0.003) compared to control subjects.CONCLUSIONS: A polymorphism in MHC2TA was associated with cardiovascular mortality and predictors of cardiovascular mortality, microalbuminuria and MetS.
  • Identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0000064