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The impact of maternal childhood abuse on maternal and infant HPA axis function in the postpartum period

Brand, Sarah R ; Brennan, Patricia A ; Newport, D. Jeffrey ; Smith, Alicia K ; Weiss, Tamara ; Stowe, Zachary N

Psychoneuroendocrinology, 2010, Vol.35(5), pp.686-693 [Peer Reviewed Journal]

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  • Title:
    The impact of maternal childhood abuse on maternal and infant HPA axis function in the postpartum period
  • Author/Creator: Brand, Sarah R ; Brennan, Patricia A ; Newport, D. Jeffrey ; Smith, Alicia K ; Weiss, Tamara ; Stowe, Zachary N
  • Language: English
  • Subjects: Early Life Stress ; Hpa Axis ; Depression ; Child ; Cortisol ; Early Life Stress ; Hpa Axis ; Depression ; Child ; Cortisol ; Medicine ; Anatomy & Physiology
  • Is Part Of: Psychoneuroendocrinology, 2010, Vol.35(5), pp.686-693
  • Description: Early life trauma, particularly child abuse, has been associated with aberrations in hypothalamic–pituitary–adrenal (HPA) axis functioning in adulthood. However, the relationship of early abuse and later adult neuroendocrine changes may be moderated by additional factors such as comorbid psychopathology and recent life stress. Parental exposure to child abuse may have transgenerational effects, with offspring of abuse victims showing similar neuroendocrine profiles as their mothers. The majority of previous studies in this area focus on adult offspring, and the degree to which the effects of parental child abuse can be detected earlier in the development of the offspring remains obscure. The current study utilized a clinical sample of women with a history of MDD ( N = 126), to examine the effects of maternal early life sexual and physical abuse (Childhood Trauma Questionnaire (CTQ)) on both maternal and infant salivary cortisol levels during a laboratory...
  • Identifier: ISSN: 0306-4530 ; E-ISSN: 1873-3360 ; DOI: 10.1016/j.psyneuen.2009.10.009