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Patient-Specific Titanium-Reinforced Calcium Phosphate Implant for the Repair and Healing of Complex Cranial Defects

Kihlström Burenstam Linder, Lars ; Birgersson, Ulrik ; Lundgren, Kalle ; Illies, Christopher ; Engstrand, Thomas

World Neurosurgery, February 2019, Vol.122, pp.e399-e407 [Peer Reviewed Journal]

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  • Title:
    Patient-Specific Titanium-Reinforced Calcium Phosphate Implant for the Repair and Healing of Complex Cranial Defects
  • Author/Creator: Kihlström Burenstam Linder, Lars ; Birgersson, Ulrik ; Lundgren, Kalle ; Illies, Christopher ; Engstrand, Thomas
  • Language: English
  • Subjects: 3-Dimensional ; Bone Regeneration ; Calcium Phosphate ; Ceramic ; Cranial ; Cranioplasty ; 3-Dimensional ; Bone Regeneration ; Calcium Phosphate ; Ceramic ; Cranial ; Cranioplasty ; Cap ; Cap-Ti ; CT ; Peek ; Pekk ; Pmma ; Ti ; TM
  • Is Part Of: World Neurosurgery, February 2019, Vol.122, pp.e399-e407
  • Description: The reconstruction of complex cranial defects is challenging and is associated with a high complication rate. The development of a patient-specific, titanium-reinforced, calcium phosphate–based (CaP-Ti) implant with bone regenerative properties has previously been described in 2 case studies with the hypothesis that the implant may improve clinical outcome. To identify whether the introduction of CaP-Ti implant has the potential to improve clinical outcome. A retrospective review of all patients having undergone CaP-Ti cranioplasty was conducted. Comprehensive clinical data were collected from the hospital computer database and patient records. Bone formation and osseointegration were analyzed in a single retrieval specimen. Fifty patients, with 52 cranial defects, met the inclusion criteria. The patient cohort displayed a previous failure rate of 64% (32/50) with autologous bone, alloplastic materials, or both. At a median...
  • Identifier: ISSN: 1878-8750 ; E-ISSN: 1878-8769 ; DOI: 10.1016/j.wneu.2018.10.061