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Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship

Von Wowern, Fredrik ; Berglund, Garan ; Carlson, Joyce ; Mansson, Henrik ; Hedblad, B.O ; Melander, Olle

Kidney International, November 2005, Vol.68(5), pp.2164-2172 [Peer Reviewed Journal]

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  • Title:
    Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship
  • Author/Creator: Von Wowern, Fredrik ; Berglund, Garan ; Carlson, Joyce ; Mansson, Henrik ; Hedblad, B.O ; Melander, Olle
  • Language: English
  • Subjects: Sgk-1 ; Genetics ; Hypertension ; Blood Pressure ; Insulin ; Sgk-1 ; Genetics ; Hypertension ; Blood Pressure ; Insulin ; Medicine
  • Is Part Of: Kidney International, November 2005, Vol.68(5), pp.2164-2172
  • Description: Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. Insulin stimulation of the serum- and glucocorticoid-regulated kinase 1 (SGK-1) prolongs the half-life of the epithelial sodium channel, a protein which is essential for blood pressure regulation. The aim of this study was to investigate if variation in the SGK-1 gene is associated with increased blood pressure and strength of the insulin-blood pressure relationship. A promoter C/T, an intron 6 C/T and an exon 8C/T polymorphism in the SGK-1 gene were genotyped in 4830 subjects from the Malmo Diet and Cancer (MDC) material of whom 4001 were free from antihypertensive medication. Of these, 2171 subjects had also been investigated 11.2 ± 4.4 years earlier in the Malmo Preventive Project (MPP). In untreated MDC subjects, intron 6CC genotype carriers had higher diastolic...
  • Identifier: ISSN: 0085-2538 ; E-ISSN: 1523-1755 ; DOI: 10.1111/j.1523-1755.2005.00672.x