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Role of Polychlorinated Dibenzofuran in Yusho (PCB Poisoning)

Kashimoto, Takashi ; Miyata, Hideaki ; Kunita, Shinji ; Tung, Ta-Cheng ; Hsu, Shu-Tao ; Chang, King-Jen ; Tang, Shu-Ying ; Ohi, Gen ; Nakagawa, Junichi ; Yamamoto, Shun-Ichi

Archives of Environmental Health: An International Journal, 01 November 1981, Vol.36(6), pp.321-326 [Peer Reviewed Journal]

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  • Title:
    Role of Polychlorinated Dibenzofuran in Yusho (PCB Poisoning)
  • Author/Creator: Kashimoto, Takashi ; Miyata, Hideaki ; Kunita, Shinji ; Tung, Ta-Cheng ; Hsu, Shu-Tao ; Chang, King-Jen ; Tang, Shu-Ying ; Ohi, Gen ; Nakagawa, Junichi ; Yamamoto, Shun-Ichi
  • Language: English
  • Subjects: Medicine ; Environmental Sciences
  • Is Part Of: Archives of Environmental Health: An International Journal, 01 November 1981, Vol.36(6), pp.321-326
  • Description: In the blood of 15 patients with Yusho or "polychlorinated biphenyl poisoning" that occurred in 1979 in Taiwan, was found poiychlorinilted dibenzofurans (14 of 15) and polychlorinated quaterphenyls (15 of 15), as well as polychlorinated biphenyls (15 of 15). The mean concentration ratio of these substances was approximately 1 : 160 : 500. Based on the following evidence, we propose that polychlorinated quaterphenyls were major pathogenic substances in the development of Yusho: (1) Clinical manifestations and course of Yusho patients are disproportionately severe and persistent for the observed blood levels of polychlorinated biphenyls, while patients who were occupationally exposed to pure polychlorinated biphenyls take characteristically mild and benign clinical course despite polychlorinated biphenyl levels often much higher than those noted in Yusho patients; (2) Polychlorinated debenzofurans show a marked tendency to accumulate in the liver, which might explain frequent presence...
  • Identifier: ISSN: 0003-9896 ; E-ISSN: 2331-4303 ; DOI: 10.1080/00039896.1981.10667645