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Brachial Artery Responses to Ambient Pollution, Temperature, and Humidity in People with Type 2 Diabetes: A Repeated-Measures Study

Zanobetti, Antonella ; Luttmann-Gibson, Heike ; Horton, Edward ; Cohen, Allison ; Coull, Brent ; Hoffmann, Barbara ; Schwartz, Joel ; Mittleman, Murray ; Li, Yongsheng ; Stone, Peter ; Desouza, Celine ; Lamparello, Brooke ; Koutrakis, Petros ; Gold, Diane

Environmental Health Perspectives (Online), Mar 2014, Vol.122(3), p.242 [Peer Reviewed Journal]

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  • Title:
    Brachial Artery Responses to Ambient Pollution, Temperature, and Humidity in People with Type 2 Diabetes: A Repeated-Measures Study
  • Author/Creator: Zanobetti, Antonella ; Luttmann-Gibson, Heike ; Horton, Edward ; Cohen, Allison ; Coull, Brent ; Hoffmann, Barbara ; Schwartz, Joel ; Mittleman, Murray ; Li, Yongsheng ; Stone, Peter ; Desouza, Celine ; Lamparello, Brooke ; Koutrakis, Petros ; Gold, Diane
  • Language: English
  • Subjects: Temperature ; Veins & Arteries ; Mortality ; Heart Attacks ; Coronary Vessels
  • Is Part Of: Environmental Health Perspectives (Online), Mar 2014, Vol.122(3), p.242
  • Description: Background: Extreme weather and air pollution are associated with increased cardiovascular risk in people with diabetes. Objectives: In a population with diabetes, we conducted a novel assessment of vascular brachial artery responses both to ambient pollution and to weather (temperature and water vapor pressure, a measure of humidity). Methods: Sixty-four 49- to 85-year-old Boston residents with type 2 diabetes completed up to five study visits (279 repeated measures). Brachial artery diameter (BAD) was measured by ultrasound before and after brachial artery occlusion [i.e., flow-mediated dilation (FMD)] and before and after nitroglycerin-mediated dilation (NMD). Ambient concentrations of fine particulate mass (PM2.5), black carbon (BC), organic carbon (OC), elemental carbon, particle number, and sulfate were measured at our monitoring site; ambient concentrations of carbon monoxide, nitrogen dioxide, and ozone were obtained from state monitors. Particle exposure in the home and during...
  • Identifier: E-ISSN: 15529924 ; DOI: 10.1289/ehp.1206136