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Investigation of the photochemical properties and in vitro phototoxic potential of bumetanide

Fiori, Jessica ; Ballardini, Roberto ; Hrelia, Patrizia ; Andrisano, Vincenza ; Tarozzi, Andrea ; Cavrini, Vanni

Photochemical & Photobiological Sciences, 2003, Vol.2(10), pp.1011-1017 [Peer Reviewed Journal]

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  • Title:
    Investigation of the photochemical properties and in vitro phototoxic potential of bumetanide
  • Author/Creator: Fiori, Jessica ; Ballardini, Roberto ; Hrelia, Patrizia ; Andrisano, Vincenza ; Tarozzi, Andrea ; Cavrini, Vanni
  • Subjects: Bumetanide -- Chemistry
  • Is Part Of: Photochemical & Photobiological Sciences, 2003, Vol.2(10), pp.1011-1017
  • Description: The photophysical and photochemical properties of bumetanide, a sulfonamide diuretic drug, have been investigated and the photodegradation of the drug on exposure to UV-B and UV-A radiation monitored by fluorimetric and chromatographic (HPLC) methods. The main photoproducts were isolated by solid-phase extraction and liquid chromatographic procedures, and their structure elucidated by 1 H-NMR and mass spectrometry. Bumetanide generates only extremely small quantities of singlet oxygen ( 1 O 2 ) upon irradiation in the presence of oxygen. The in vitro 3T3 NRU phototoxicity test yielded no evidence of phototoxic action.
  • Identifier: ISSN: 1474-905X ; E-ISSN: 1474-9092 ; DOI: 10.1039/b302922k