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Challenges in estimating the validity of dietary acrylamide measurements

Ferrari, Pietro ; Freisling, Heinz ; Duell, Eric ; Kaaks, Rudolf ; Lujan-Barroso, Leila ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Nailler, Laura ; Polidoro, Silvia ; Mattiello, Amalia ; Palli, Domenico ; Tumino, Rosario ; Grioni, Sara ; Knüppel, Sven ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Orfanos, Philippos ; Katsoulis, Michail ; Trichopoulou, Antonia ; Quirós, Jose ; Ardanaz, Eva ; Huerta, José ; Etxezarreta, Pilar ; Sánchez, María ; Crowe, Francesca ; Khaw, Kay-Tee ; Wareham, Nicholas ; Ocke, Marga ; Bueno-de-Mesquita, Bas ; Peeters, Petra ; Ericson, Ulrika ; Wirfält, Elisabet ; Hallmans, Göran ; Johansson, Ingegerd ; Engeset, Dagrun ; Nicolas, Geneviève ; Gallo, Valentina ; Norat, Teresa ; Riboli, Elio ; Slimani, Nadia

European Journal of Nutrition, 2013, Vol.52(5), pp.1503-1512 [Peer Reviewed Journal]

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  • Title:
    Challenges in estimating the validity of dietary acrylamide measurements
  • Author/Creator: Ferrari, Pietro ; Freisling, Heinz ; Duell, Eric ; Kaaks, Rudolf ; Lujan-Barroso, Leila ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Nailler, Laura ; Polidoro, Silvia ; Mattiello, Amalia ; Palli, Domenico ; Tumino, Rosario ; Grioni, Sara ; Knüppel, Sven ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Orfanos, Philippos ; Katsoulis, Michail ; Trichopoulou, Antonia ; Quirós, Jose ; Ardanaz, Eva ; Huerta, José ; Etxezarreta, Pilar ; Sánchez, María ; Crowe, Francesca ; Khaw, Kay-Tee ; Wareham, Nicholas ; Ocke, Marga ; Bueno-de-Mesquita, Bas ; Peeters, Petra ; Ericson, Ulrika ; Wirfält, Elisabet ; Hallmans, Göran ; Johansson, Ingegerd ; Engeset, Dagrun ; Nicolas, Geneviève ; Gallo, Valentina ; Norat, Teresa ; Riboli, Elio ; Slimani, Nadia
  • Language: English
  • Subjects: Acrylamide ; Dietary questionnaires ; Haemoglobin adducts ; Biomarkers ; Smoking ; Measurement errors
  • Is Part Of: European Journal of Nutrition, 2013, Vol.52(5), pp.1503-1512
  • Description: Byline: Pietro Ferrari (1), Heinz Freisling (1), Eric J. Duell (2), Rudolf Kaaks (3), Leila Lujan-Barroso (2,4), Francoise Clavel-Chapelon (5), Marie-Christine Boutron-Ruault (5), Laura Nailler (5), Silvia Polidoro (6), Amalia Mattiello (7), Domenico Palli (8), Rosario Tumino (9), Sara Grioni (10), Sven Knuppel (11), Anne Tjonneland (12), Anja Olsen (12), Kim Overvad (13), Philippos Orfanos (14,15), Michail Katsoulis (14,15), Antonia Trichopoulou (14,15), Jose Ramon Quiros (16), Eva Ardanaz (17,18), Jose Maria Huerta (18,19), Pilar Amiano Etxezarreta (20), Maria Jose Sanchez (21), Francesca Crowe (22), Kay-Tee Khaw (23), Nicholas J. Wareham (24), Marga Ocke (25), Bas Bueno-de-Mesquita (25,26), Petra H. M. Peeters (27), Ulrika Ericson (28), Elisabet Wirfalt (29), Goran Hallmans (30), Ingegerd Johansson (31), Dagrun Engeset (32), Genevieve Nicolas (1), Valentina Gallo (33), Teresa Norat (33), Elio Riboli (33), Nadia Slimani (1) Keywords: Acrylamide; Dietary questionnaires; Haemoglobin adducts; Biomarkers; Smoking; Measurement errors Abstract: Background Acrylamide is a chemical compound present in tobacco smoke and food, classified as a probable human carcinogen and a known human neurotoxin. Acrylamide is formed in foods, typically carbohydrate-rich and protein-poor plant foods, during high-temperature cooking or other thermal processing. The objectives of this study were to compare dietary estimates of acrylamide from questionnaires (DQ) and 24-h recalls (R) with levels of acrylamide adduct (AA) in haemoglobin. Methods In the European Prospective Investigation into Cancer and Nutrition (EPIC) study, acrylamide exposure was assessed in 510 participants from 9 European countries, randomly selected and stratified by age, sex, with equal numbers of never and current smokers. After adjusting for country, alcohol intake, smoking status, number of cigarettes and energy intake, correlation coefficients between various acrylamide measurements were computed, both at the individual and at the aggregate (centre) level. Results Individual level correlation coefficient between DQ and R measurements (r .sub.DQ,R) was 0.17, while r .sub.DQ,AA and r .sub.R,AA were 0.08 and 0.06, respectively. In never smokers, r .sub.DQ,R, r .sub.DQ,AA and r .sub.R,AA were 0.19, 0.09 and 0.02, respectively. The correlation coefficients between means of DQ, R and AA measurements at the centre level were larger (r > 0.4). Conclusions These findings suggest that estimates of total acrylamide intake based on self-reported diet correlate weakly with biomarker AA Hb levels. Possible explanations are the lack of AA levels to capture dietary acrylamide due to individual differences in the absorption and metabolism of acrylamide, and/or measurement errors in acrylamide from self-reported dietary assessments, thus limiting the possibility to validate acrylamide DQ measurements. Author Affiliation: (1) International Agency for Research on Cancer (IARC-WHO), Lyon, France (2) Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain (3) Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany (4) Biostatistics, Department of Public Health, University of Barcelona, Barcelona, Spain (5) Inserm, Centre for Research in Epidemiology and Population Health, U1018, Institut Gustave Roussy, 94805, Villejuif, France (6) Human Genetic Foundation (HuGeF), Torino, Italy (7) Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy (8) Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy (9) Cancer Registry and Histopathology Unit, "Civile, M.P.Arezzo" Hospital, ASP Ragusa, Italy (10) Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (11) Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (12) Danish Cancer Society Research Center, Copenhagen, Denmark (13) Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark (14) Hellenic Health Foundation, 10-12 Tetrapoleos Street, 115 27, Athens, Greece (15) WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, 115 27, Athens, Greece (16) Public Health Directorate, Asturias, Spain (17) Navarre Public Health Institute, Pamplona, Spain (18) CIBER Epidemiology and Public Health CIBERESP, Barcelona, Spain (19) Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain (20) Public Health Division of Gipuzkoa, Donostia-San Sebastian, Spain (21) Registro de Cancer de Granada, Escuela Andaluza de Salud Publica, Granada, Spain (22) Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK (23) Department of Public Health and Primary Care, University of Cambridge Addenbrooke's Hospital, Cambridge, UK (24) MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK (25) National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands (26) Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands (27) Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (28) Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences in Malmo, Lund University, Lund, Sweden (29) Nutritional Epidemiology, Department of Clinical Sciences in Malmo, Lund University, Lund, Sweden (30) Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden (31) Department of Odontology, Umea University, Umea, Sweden (32) Department of Community Medicine, University of Tromso, Tromso, Norway (33) Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Article History: Registration Date: 16/10/2012 Received Date: 21/05/2012 Accepted Date: 16/10/2012 Online Date: 01/11/2012 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s00394-012-0457-7) contains supplementary material, which is available to authorized users.
  • Identifier: ISSN: 1436-6207 ; E-ISSN: 1436-6215 ; DOI: 10.1007/s00394-012-0457-7