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Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Michaud, Dominique ; Izard, Jacques ; Rubin, Zachary ; Johansson, Ingegerd ; Weiderpass, Elisabete ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie ; Clavel-Chapelon, Françoise ; Dossus, Laure ; Kaaks, Rudolf ; Katzke, Verena ; Boeing, Heiner ; Foerster, Jana ; Trichopoulou, Antonia ; Naska, Androniki ; Ziara, Giana ; Vineis, Paolo ; Grioni, Sara ; Palli, Domenico ; Tumino, Rosario ; Mattiello, Amalia ; Peeters, Petra ; Siersema, Peter ; Barricarte, Aurelio ; Huerta, José-María ; Molina-Montes, Esther ; Dorronsoro, Miren ; Quirós, J. ; Duell, Eric ; Ohlsson, Bodil ; Jeppsson, Bengt ; Johansson, Anders ; Lif, Pernilla ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Ruth ; Key, Tim ; Freisling, Heinz ; Duarte-Salles, Talita ; Stepien, Magdalena ; Riboli, Elio ; Bueno-de-Mesquita, H.

Cancer Causes & Control, 2013, Vol.24(11), pp.1901-1909 [Peer Reviewed Journal]

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  • Title:
    Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study
  • Author/Creator: Michaud, Dominique ; Izard, Jacques ; Rubin, Zachary ; Johansson, Ingegerd ; Weiderpass, Elisabete ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie ; Clavel-Chapelon, Françoise ; Dossus, Laure ; Kaaks, Rudolf ; Katzke, Verena ; Boeing, Heiner ; Foerster, Jana ; Trichopoulou, Antonia ; Naska, Androniki ; Ziara, Giana ; Vineis, Paolo ; Grioni, Sara ; Palli, Domenico ; Tumino, Rosario ; Mattiello, Amalia ; Peeters, Petra ; Siersema, Peter ; Barricarte, Aurelio ; Huerta, José-María ; Molina-Montes, Esther ; Dorronsoro, Miren ; Quirós, J. ; Duell, Eric ; Ohlsson, Bodil ; Jeppsson, Bengt ; Johansson, Anders ; Lif, Pernilla ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Ruth ; Key, Tim ; Freisling, Heinz ; Duarte-Salles, Talita ; Stepien, Magdalena ; Riboli, Elio ; Bueno-de-Mesquita, H.
  • Language: English
  • Subjects: Antibodies to oral bacteria ; Smoking ; Lifestyle factors
  • Is Part Of: Cancer Causes & Control, 2013, Vol.24(11), pp.1901-1909
  • Description: Byline: Dominique S. Michaud (1,2), Jacques Izard (3,4), Zachary Rubin (1), Ingegerd Johansson (5,6), Elisabete Weiderpass (6,7,8,9), Anne Tjonneland (10), Anja Olsen (10), Kim Overvad (11), Marie Christine Boutron-Ruault (12,13), Francoise Clavel-Chapelon (12,13), Laure Dossus (12,13), Rudolf Kaaks (14), Verena A. Katzke (14), Heiner Boeing (15), Jana Foerster (15), Antonia Trichopoulou (16,17), Androniki Naska (16), Giana Ziara (17), Paolo Vineis (2,18), Sara Grioni (19), Domenico Palli (20), Rosario Tumino (21), Amalia Mattiello (22), Petra H. M. Peeters (23), Peter D. Siersema (24), Aurelio Barricarte (25,26), Jose-Maria Huerta (26,27), Esther Molina-Montes (26,28), Miren Dorronsoro (29), J. Ramon Quiros (30), Eric J. Duell (31), Bodil Ohlsson (32), Bengt Jeppsson (33), Anders Johansson (5), Pernilla Lif (5), Kay-Tee Khaw (34), Nick Wareham (35), Ruth C. Travis (36), Tim J. Key (36), Heinz Freisling (37), Talita Duarte-Salles (37), Magdalena Stepien (37), Elio Riboli (2), H. Bas Bueno-de-Mesquita (24,38) Keywords: Antibodies to oral bacteria; Smoking; Lifestyle factors Abstract: Background Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Methods Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. Results IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Conclusions Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria. Author Affiliation: (1) Department of Epidemiology, School of Public Health, Brown University, Box G-S121-2, Providence, RI, 02912, USA (2) School of Public Health, Imperial College London, London, UK (3) The Forsyth Institute, Cambridge, MA, USA (4) Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA (5) Department of Odontology/Cardiology, Umea University, Umea, Sweden (6) Samfundet Folkhalsan, Helsinki, Finland (7) Department of Community Medicine, Faculty of Health Sciences, University of Tromso, Tromso, Norway (8) Department of Research, Cancer Registry of Norway, Oslo, Norway (9) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (10) Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark (11) Department of Public Health, Aarhus University, Arhus, Denmark (12) Inserm, Centre for Research in Epidemiology and Population Health, U1018, Institut Gustave Roussy, 94805, Villejuif, France (13) Paris South University, UMRS 1018, 94805, Villejuif, France (14) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (15) Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (16) WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece (17) Hellenic Health Foundation, Athens, Greece (18) Center for Cancer Prevention (CPO-Piemonte) and Human Genetic Foundation (HuGeF), Turin, Italy (19) Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (20) Molecular and Nutritional Epidemiology Unit, ISPO, Cancer Research and Prevention Institute, Florence, Italy (21) Cancer Registry and Histopathology Unit, "Civile-M.P.Arezzo" Hospital, ASP 7, Ragusa, Italy (22) Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy (23) Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (24) Department of Gastroenterology and Hepatology, University Medical Centre Utrecht (UMCU), Utrecht, The Netherlands (25) Public Health Institute of Navarra, Pamplona, Spain (26) CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (27) Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain (28) Andalusian School of Public Health, Granada, Spain (29) Public Health Division of Gipuzkoa, Basque Regional Health Department, San Sebastian, Spain (30) Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain (31) Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain (32) Division of Gastroenterology, Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden (33) Department of Surgery, Lund University and Skane University Hospital, Malmo, Sweden (34) School of Clinical Medicine, University of Cambridge, Cambridge, UK (35) MRC Epidemiology Unit, Cambridge, UK (36) Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK (37) International Agency for Research on Cancer (IARC-WHO), Lyon, France (38) National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands Article History: Registration Date: 15/07/2013 Received Date: 20/03/2013 Accepted Date: 15/07/2013 Online Date: 31/07/2013 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s10552-013-0265-2) contains supplementary material, which is available to authorized users.
  • Identifier: ISSN: 0957-5243 ; E-ISSN: 1573-7225 ; DOI: 10.1007/s10552-013-0265-2