skip to main content
Resource type Show Results with: Show Results with: Index

Prenatal air pollution exposure and newborn blood pressure

Van Rossem, Lenie ; Rifas - Shiman, Sheryl L. ; Melly, Steven J. ; Kloog, Itai ; Luttmann - Gibson, Heike ; Zanobetti, Antonella ; Coull, Brent A. ; Schwartz, Joel D. ; Mittleman, Murray A. ; Oken, Emily ; Gillman, Matthew W. ; Koutrakis, Petros ; Gold, Diane R.

Environmental Health Perspectives 123(4), 353-359 (2015)

Link to full text

Citations Cited by
  • Title:
    Prenatal air pollution exposure and newborn blood pressure
  • Author/Creator: Van Rossem, Lenie ; Rifas - Shiman, Sheryl L. ; Melly, Steven J. ; Kloog, Itai ; Luttmann - Gibson, Heike ; Zanobetti, Antonella ; Coull, Brent A. ; Schwartz, Joel D. ; Mittleman, Murray A. ; Oken, Emily ; Gillman, Matthew W. ; Koutrakis, Petros ; Gold, Diane R.
  • Language: English
  • Subjects: Health, Toxicology And Mutagenesis ; Public Health, Environmental And Occupational Health ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov'T, Non-P.H.S.
  • Is Part Of: Environmental Health Perspectives 123(4), 353-359 (2015)
  • Description: Background: Air pollution exposure has been associated with increased blood pressure in adults. oBjective: We examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP). Methods: We studied 1,131 mother–infant pairs in a Boston, Massachusetts, area pre-birth cohort. We calculated average exposures by trimester and during the 2 to 90 days before birth for temporally resolved fine particulate matter (≤ 2.5 μm; PM2.5), black carbon (BC), nitrogen oxides, nitrogen dioxide, ozone (O3), and carbon monoxide measured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at the residence level. We measured SBP at a mean age of 30 ± 18 hr with an automated device. We used mixed-effects models to examine associations between air pollutant exposures and SBP, taking into account measurement circumstances; child’s birth weight; mother’s age, race/ethnicity, socioeconomic position, and third-trimester BP; and time trend. Estimates represent differences in SBP associated with an interquar-tile range (IQR) increase in each pollutant. results: Higher mean PM2.5 and BC exposures during the third trimester were associated with higher SBP (e.g., 1.0 mmHg; 95% CI: 0.1, 1.8 for a 0.32-μg/m3 increase in mean 90-day residen-tial BC). In contrast, O3 was negatively associated with SBP (e.g., –2.3 mmHg; 95% CI: –4.4, –0.2 for a 13.5-ppb increase during the 90 days before birth). conclusions: Exposures to PM2.5 and BC in late pregnancy were positively associated with newborn SBP, whereas O3 was negatively associated with SBP. Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.