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The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma

Du, Ya-Bing ; Dong, Bin ; Shen, Lu-Yan ; Yan, Wan-Pu ; Dai, Liang ; Xiong, Hong-Chao ; Liang, Zhen ; Kang, Xiao-Zheng ; Qin, Bin ; Chen, Ke-Neng

Journal of Surgical Research, 15 May 2014, Vol.188(2), pp.442-450 [Peer Reviewed Journal]

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  • Title:
    The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma
  • Author/Creator: Du, Ya-Bing ; Dong, Bin ; Shen, Lu-Yan ; Yan, Wan-Pu ; Dai, Liang ; Xiong, Hong-Chao ; Liang, Zhen ; Kang, Xiao-Zheng ; Qin, Bin ; Chen, Ke-Neng
  • Language: English
  • Subjects: Hoxc6 ; Hoxc8 ; Ihc ; Escc
  • Is Part Of: Journal of Surgical Research, 15 May 2014, Vol.188(2), pp.442-450
  • Description: Esophageal squamous cell carcinoma (ESCC), a common disease in China, is mainly treated surgically. We established a prospective database of patients with esophageal cancer between January 2000 and December 2010, including 486 subjects with ESCC who underwent surgical treatment. In this study, we explored the prognostic significance of the expressions of HOXC6 and HOXC8, responsible for embryonic development, by studying the specimens collected from clinical subjects during strict follow-up periods. Immunohistochemistry was used to detect the expressions of HOXC6 and HOXC8 in 274 ESCC subjects including 138 ESCC subjects treated with surgery alone and 136 ESCC subjects treated with neoadjuvant chemotherapy. Survival analysis was performed from the day of surgery to August 2013. The 5-y survival rate of the 274 ESCC subjects was 44.2%, with a median survival time of 44.12 mo. For the 274 ESCC subjects involved in the investigation of HOXC6...
  • Identifier: ISSN: 0022-4804 ; E-ISSN: 1095-8673 ; DOI: 10.1016/j.jss.2014.01.017