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Associations Between Short-term Changes in Air Pollution and Correlates of Arterial Stiffness: The Veterans Affairs Normative Aging Study, 2007–2011

Mehta, Amar J ; Zanobetti, Antonella ; Koutrakis, Petros ; Mittleman, Murray A ; Sparrow, David ; Vokonas, Pantel ; Schwartz, Joel

American Journal of Epidemiology, 2014, Vol. 179(2), pp.192-199 [Peer Reviewed Journal]

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  • Title:
    Associations Between Short-term Changes in Air Pollution and Correlates of Arterial Stiffness: The Veterans Affairs Normative Aging Study, 2007–2011
  • Author/Creator: Mehta, Amar J ; Zanobetti, Antonella ; Koutrakis, Petros ; Mittleman, Murray A ; Sparrow, David ; Vokonas, Pantel ; Schwartz, Joel
  • Subjects: Air Pollution ; Particulate Matter ; Pulse Wave Analysis
  • Is Part Of: American Journal of Epidemiology, 2014, Vol. 179(2), pp.192-199
  • Description: We investigated associations between short-term exposure to air pollution and central augmentation index and augmentation pressure, correlates of arterial stiffness, in a cohort of elderly men in the Boston, Massachusetts, metropolitan area. This longitudinal analysis included 370 participants from the Veterans Affairs Normative Aging Study with up to 2 visits between 2007 and 2011 ( n = 445). Augmentation index (as %) and augmentation pressure (in mmHg) were measured at each visit by using radial artery applanation tonometry for pulse wave analysis and modeled in a mixed effects regression model as continuous functions of moving averages of air pollution exposures (over 4 hours and 1, 3, 7, and 14 days). The results suggest that short-term changes in air pollution were associated with augmentation index and augmentation pressure at several moving averages. Interquartile range (IQR) increases in 3-day average exposure to particles with aerodynamic diameter less than 2.5 μm (3.6-μg/m 3 IQR increase) and sulfate (1.4-μg/m 3 IQR increase) and 1-day average exposure to particle number counts (8,741-counts/cm 3 IQR increase) were associated with augmentation index values that were 0.8% (95% confidence interval (CI): 0.2, 1.4), 0.6% (95% CI: 0.1, 1.2), and 1.7% (95% CI: 0.4, 2.9) higher, respectively. Overall, the findings were similar for augmentation pressure. The findings support the hypothesis that exposure to air pollution may affect vascular function.
  • Identifier: ISSN: 0002-9262 ; E-ISSN: 1476-6256 ; DOI: 10.1093/aje/kwt271