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Improved Air Quality and Attenuated Lung Function Decline: Modification by Obesity in the SAPALDIA Cohort

Schikowski, Tamara ; Schaffner, Emmanuel ; Meier, Flurina ; Phuleria, Harish C ; Vierkötter, Andrea ; Schindler, Christian ; Kriemler, Susi ; Zemp, Elisabeth ; Krämer, Ursula ; Bridevaux, Pierre-Olivier ; Rochat, Thierry ; Schwartz, Joel ; Künzli, Nino ; Probst-Hensch, Nicole

Environmental Health Perspectives, 2013, Vol.121(9), p.1034-1039 [Peer Reviewed Journal]

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  • Title:
    Improved Air Quality and Attenuated Lung Function Decline: Modification by Obesity in the SAPALDIA Cohort
  • Author/Creator: Schikowski, Tamara ; Schaffner, Emmanuel ; Meier, Flurina ; Phuleria, Harish C ; Vierkötter, Andrea ; Schindler, Christian ; Kriemler, Susi ; Zemp, Elisabeth ; Krämer, Ursula ; Bridevaux, Pierre-Olivier ; Rochat, Thierry ; Schwartz, Joel ; Künzli, Nino ; Probst-Hensch, Nicole
  • Subjects: Research
  • Is Part Of: Environmental Health Perspectives, 2013, Vol.121(9), p.1034-1039
  • Description: Background: Air pollution and obesity are hypothesized to contribute to accelerated decline in lung function with age through their inflammatory properties. Objective: We investigated whether the previously reported association between improved air quality and lung health in the population-based SAPALDIA cohort is modified by obesity. Methods: We used adjusted mixed-model analyses to estimate the association of average body mass index (BMI) and changes in particulate matter with aerodynamic diameter ≤ 10 µm (PM 10 ; ΔPM 10 ) with lung function decline over a 10-year follow-up period. Results: Lung function data and complete information were available for 4,664 participants. Age-related declines in lung function among participants with high average BMI were more rapid for FVC (forced vital capacity), but slower for FEV 1 /FVC (forced expiratory volume in 1 sec/FVC) and FEF 25–75 (forced expiratory flow at 25–75%) than declines among those with low or normal average BMI. Improved air quality was associated with attenuated reductions in FEV 1 /FVC, FEF 25–75 , and FEF 25–75 /FVC over time among low- and normal-BMI participants, but not overweight or obese participants. The attenuation was most pronounced for ΔFEF 25–75 /FVC (30% and 22% attenuation in association with a 10-μg/m 3 decrease in PM 10 among low- and normal-weight participants, respectively.) Conclusion: Our results point to the importance of considering health effects of air pollution exposure and obesity in parallel. Further research must address the mechanisms underlying the observed interaction. Citation: Schikowski T, Schaffner E, Meier F, Phuleria HC, Vierkötter A, Schindler C, Kriemler S, Zemp E, Krämer U, Bridevaux P-O, Rochat T, Schwartz J, Künzli N, Probst-Hensch N. 2013. Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort. Environ Health Perspect 121:1034–1039; http://dx.doi.org/10.1289/ehp.1206145
  • Identifier: ISSN: 0091-6765 ; E-ISSN: 1552-9924 ; DOI: 10.1289/ehp.1206145 ; PMCID: 3764076 ; PMID: 23820868