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Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Lujan-Barroso, Leila ; González, Carlos ; Slimani, Nadia ; Obón-Santacana, Mireia ; Ferrari, Pietro ; Freisling, Heinz ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Racine, Antoine ; Katzke, Verena ; Kühn, Tilman ; Tjønneland, Anne ; Olsen, Anja ; Quirós, J. ; Sánchez-Cantalejo, Emilio ; Amiano, Pilar ; Navarro, Carmen ; Barricarte, Aurelio ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Ruth ; Trichopoulou, Antonia ; Bamia, Christina ; Benetou, Vassiliki ; Saieva, Calogero ; Grioni, Sara ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Bueno-de-Mesquita, H. ; Siersema, Peter ; Numans, Mattijs ; Peeters, Petra ; Ericson, Ulrika ; Wirfält, Elisabet ; Sund, Malin ; Johansson, Mattias ; Weiderpass, Elisabete ; Skeie, Guri ; Riboli, Elio ; Boeing, Heiner ; Duell, Eric

Cancer Causes & Control, 2014, Vol.25(5), pp.639-646 [Peer Reviewed Journal]

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  • Title:
    Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
  • Author/Creator: Lujan-Barroso, Leila ; González, Carlos ; Slimani, Nadia ; Obón-Santacana, Mireia ; Ferrari, Pietro ; Freisling, Heinz ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Racine, Antoine ; Katzke, Verena ; Kühn, Tilman ; Tjønneland, Anne ; Olsen, Anja ; Quirós, J. ; Sánchez-Cantalejo, Emilio ; Amiano, Pilar ; Navarro, Carmen ; Barricarte, Aurelio ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Ruth ; Trichopoulou, Antonia ; Bamia, Christina ; Benetou, Vassiliki ; Saieva, Calogero ; Grioni, Sara ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Bueno-de-Mesquita, H. ; Siersema, Peter ; Numans, Mattijs ; Peeters, Petra ; Ericson, Ulrika ; Wirfält, Elisabet ; Sund, Malin ; Johansson, Mattias ; Weiderpass, Elisabete ; Skeie, Guri ; Riboli, Elio ; Boeing, Heiner ; Duell, Eric
  • Language: English
  • Subjects: Esophageal cancer ; Esophageal squamous cell carcinoma ; Esophageal adenocarcinoma ; Acrylamide intake ; Cohort ; Nutrition
  • Is Part Of: Cancer Causes & Control, 2014, Vol.25(5), pp.639-646
  • Description: Byline: Leila Lujan-Barroso (1), Carlos Alberto Gonzalez (1), Nadia Slimani (2), Mireia Obon-Santacana (1), Pietro Ferrari (2), Heinz Freisling (2), Kim Overvad (3), Francoise Clavel-Chapelon (4,5,6), Marie-Christine Boutron-Ruault (4,5,6), Antoine Racine (4,5,6), Verena Katzke (7), Tilman Kuhn (7), Anne Tjonneland (8), Anja Olsen (8), J. Ramon Quiros (9), Emilio Sanchez-Cantalejo (10), Pilar Amiano (11,12,13), Carmen Navarro (13,14,15), Aurelio Barricarte (16,17), Kay-Tee Khaw (18), Nick Wareham (18), Ruth C. Travis (19), Antonia Trichopoulou (20,21), Christina Bamia (20,21), Vassiliki Benetou (20,21), Calogero Saieva (22), Sara Grioni (23), Rosario Tumino (24), Paolo Vineis (25,26), Amalia Mattiello (27), H. Bas Bueno-de-Mesquita (28,29), Peter D. Siersema (29), Mattijs E. Numans (30,31), Petra H. Peeters (30,32), Ulrika Ericson (33), Elisabet Wirfalt (34), Malin Sund (35), Mattias Johansson (2,36), Elisabete Weiderpass (37,38,39,40), Guri Skeie (37), Elio Riboli (25), Heiner Boeing (41), Eric J. Duell (1) Keywords: Esophageal cancer; Esophageal squamous cell carcinoma; Esophageal adenocarcinoma; Acrylamide intake; Cohort; Nutrition Abstract: Purpose The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Multivariate Cox proportional hazards models were used to estimate the HR and 95 % confidence interval (95 % CI). Since nonlinear relations were observed, HRs were displayed for quartiles of acrylamide intake in ug per day. Results After a mean follow-up of 11 years, 341 EC were identified, 142 of which were EAC, 176 ESCC, and 23 other histological types or not specified. An increase in EC risk was observed in the second and third quartiles (HR.sub.Q2vsQ1 1.75, 95 % CI 1.12--2.74 HR.sub.Q3vsQ1 1.66, 95 % CI 1.05--2.61), but not in the fourth quartile, and there was no evidence for a linear dose--response trend. HRs were similarly elevated but not statistically significant when ESCC and EAC were analyzed separately, due to the small number of cases observed. No associations were observed when quartiles were based on energy-adjusted acrylamide intake. Conclusions In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acrylamide is not an important risk factor for EC. Author Affiliation: (1) Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Avda Gran Via 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain (2) International Agency for Research on Cancer (IARC-WHO), Lyon, France (3) Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark (4) Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, Villejuif, France, INSERM, Villejuif, France (5) Univesity Paris Sud, UMRS 1018, Villejuif, France (6) IGR, Villejuif, France (7) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (8) Danish Cancer Society Research Center, Copenhagen, Denmark (9) Public Health Directorate, Asturias, Spain (10) Andalusian School of Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Granada, Spain (11) Public Health Division of Gipuzkoa, San Sebastian, Spain (12) Health Department of Basque Region, BioDonostia Research Institute, San Sebastian, Spain (13) CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain (14) Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain (15) Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain (16) Navarre Public Health Institute, Pamplona, Spain (17) Consortium for Biomedical Research in Epidemiology and Public Health, CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain (18) MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (19) Cancer Epidemiology Unit, University of Oxford, Oxford, UK (20) Hellenic Health Foundation, Athens, Greece (21) WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece (22) Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy (23) Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (24) Cancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital, ASP Ragusa, Ragusa, Italy (25) School of Public Health, Imperial College London, London, UK (26) HuGeF Foundation, Turin, Italy (27) Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy (28) National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands (29) Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands (30) Department of Primary Care Julius Center, UMC, Utrecht, The Netherlands (31) Department of General Practice and Elderly Care, VUmc Amsterdam, Amsterdam, The Netherlands (32) Department of Epidemiology and Biostatistics, Imperial College London, London, UK (33) Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmo, Sweden (34) Department of Clinical Sciences, Lund University, Malmo, Sweden (35) Department of Surgery, Umea University, Umea, Sweden (36) Department of Biobank Research, Umea University, Umea, Sweden (37) Department of Community Medicine, Faculty of Health Sciences, University of Tromso, Tromso, Norway (38) Department of Research, Cancer Registry of Norway, Oslo, Norway (39) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (40) Samfundet Folkhalsan, Helsinki, Finland (41) Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrucke, Germany Article History: Registration Date: 10/02/2014 Received Date: 25/09/2013 Accepted Date: 10/02/2014 Online Date: 16/02/2014
  • Identifier: ISSN: 0957-5243 ; E-ISSN: 1573-7225 ; DOI: 10.1007/s10552-014-0359-5