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Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma

Kelly, Rachel ; Roulland, Sandrine ; Morgado, Ester ; Sungalee, Stéphanie ; Jouve, Nathalie ; Tumino, Rosario ; Krogh, Vittorio ; Panico, Salvatore ; Polidoro, Silvia ; Masala, Giovanna ; Sánchez, María-José ; Chirlaque, Maria-Dolores ; Sala, Núria ; Gurrea, Aurelio ; Dorronsoro, Miren ; Travis, Ruth ; Riboli, Elio ; Gunter, Marc ; Murphy, Neil ; Vermeulen, Roel ; Bueno-de-Mesquita, H. ; Peeters, Petra ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Lagiou, Pagona ; Nieters, Alexandra ; Canzian, Federico ; Kaaks, Rudolf ; Boeing, Heiner ; Weiderpass, Elisabete ; Stocks, Tanja ; Melin, Beatrice ; Overvad, Kim ; Tjønneland, Anne ; Olsen, Anja ; Brennan, Paul ; Johansson, Mattias ; Nadel, Bertrand ; Vineis, Paolo

Cancer Causes & Control, 2015, Vol.26(12), pp.1845-1855 [Peer Reviewed Journal]

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  • Title:
    Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma
  • Author/Creator: Kelly, Rachel ; Roulland, Sandrine ; Morgado, Ester ; Sungalee, Stéphanie ; Jouve, Nathalie ; Tumino, Rosario ; Krogh, Vittorio ; Panico, Salvatore ; Polidoro, Silvia ; Masala, Giovanna ; Sánchez, María-José ; Chirlaque, Maria-Dolores ; Sala, Núria ; Gurrea, Aurelio ; Dorronsoro, Miren ; Travis, Ruth ; Riboli, Elio ; Gunter, Marc ; Murphy, Neil ; Vermeulen, Roel ; Bueno-de-Mesquita, H. ; Peeters, Petra ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Lagiou, Pagona ; Nieters, Alexandra ; Canzian, Federico ; Kaaks, Rudolf ; Boeing, Heiner ; Weiderpass, Elisabete ; Stocks, Tanja ; Melin, Beatrice ; Overvad, Kim ; Tjønneland, Anne ; Olsen, Anja ; Brennan, Paul ; Johansson, Mattias ; Nadel, Bertrand ; Vineis, Paolo
  • Language: English
  • Subjects: Follicular lymphoma ; Translocation ; t(14; 18) ; Height
  • Is Part Of: Cancer Causes & Control, 2015, Vol.26(12), pp.1845-1855
  • Description: Byline: Rachel S. Kelly (1,2), Sandrine Roulland (3,4,5), Ester Morgado (3,4,5), Stephanie Sungalee (3,4,5), Nathalie Jouve (3,4,5), Rosario Tumino (6), Vittorio Krogh (7), Salvatore Panico (8), Silvia Polidoro (9), Giovanna Masala (10), Maria-Jose Sanchez (11,12), Maria-Dolores Chirlaque (12,13), Nuria Sala (14), Aurelio Barricarte Gurrea (12,15), Miren Dorronsoro (16), Ruth C. Travis (17), Elio Riboli (1), Marc Gunter (1), Neil Murphy (1), Roel Vermeulen (18), H. B. Bueno-de-Mesquita (19,20), Petra H. Peeters (21), Antonia Trichopoulou (22,23), Dimitrios Trichopoulos (2,22,23), Pagona Lagiou (2,23,24), Alexandra Nieters (25), Federico Canzian (26), Rudolf Kaaks (26), Heiner Boeing (27), Elisabete Weiderpass (28,29,30,31), Tanja Stocks (32,33), Beatrice Melin (34), Kim Overvad (35), Anne Tjonneland (36), Anja Olsen (36), Paul Brennan (37), Mattias Johansson (37), Bertrand Nadel (3,4,5), Paolo Vineis (1,9) Keywords: Follicular lymphoma; Translocation; t(14 18); Height Abstract: Purpose The strong association between t(14 18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14 18) associated FL remain to be established. Methods t(14 18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case--control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14 18).sup.+ as compared to t(14 18).sup.- cases. Results Among incident FL cases, educational level ([chi] .sup.2 p = 0.021) and height ([chi] .sup.2 p = 0.025) were positively associated with t(14 18) prevalence, and cases with high frequencies [t(14 18).sup.HF] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14 18).sup.+ FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14 18).sup.- cases. Conclusions These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14 18) translocation. The observation that the etiology of FL may differ by t(14 18) status, particularly with regard to height, supports the subdivision of FL by translocation status. Author Affiliation: (1) MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus Norfolk Place, London, W2 1PG, UK (2) Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA (3) Center of Immunology of Marseille-Luminy (CIML), Universite de la Mediterranee, Marseille, France (4) INSERM U631, Marseille, France (5) CNRS UMR6102, Marseille, France (6) Cancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital, ASP Ragusa, Ragusa, Italy (7) Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (8) Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy (9) HuGeF - Human Genetics Foundation, Turin, Italy (10) Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute -- ISPO, Florence, Italy (11) Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria de Granada (Granada.ibs), Granada, Spain (12) CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain (13) Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain (14) Unit of Nutrition and Cancer, Cancer Epidemiology Research Program and Translational Research Laboratory, Catalan Institute of Oncology (IDIBELL), Barcelona, Spain (15) Navarre Public Health Institute, Pamplona, Spain (16) Public Health Direction and Ciberesp-Biodonostia Basque Regional Health Department, Vitoria, Spain (17) Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK (18) Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands (19) Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands (20) Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands (21) Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands (22) Hellenic Health Foundation, 13 Kaisareias Street, 115 27, Athens, Greece (23) Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, 115 27, Athens, Greece (24) Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, 115 27, Athens, Greece (25) Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany (26) Genomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany (27) Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruucke, Nuthetal, Germany (28) Department of Community Medicine, Faculty of Health Sciences, University of Tromso, The Arctic University of Norway, Tromso, Norway (29) Cancer Registry of Norway, Oslo, Norway (30) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (31) Department of Genetic Epidemiology, Folkhalsan Research Center, Helsinki, Finland (32) Department of Clinical Sciences in Malmo, Lund University, Lund, Sweden (33) Department of Perioperative and Surgical Sciences, Umea University, Umea, Sweden (34) Department of Radiation Sciences, Head Regional Cancer Center North, Umea University, Umea, Sweden (35) Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark (36) Danish Cancer Society Research Center, Copenhagen, Denmark (37) International Agency for Research on Cancer (IARC-WHO), 69372, Lyon, France Article History: Registration Date: 22/09/2015 Received Date: 12/02/2015 Accepted Date: 22/09/2015 Online Date: 30/09/2015 Article note: Rachel S. Kelly, Sandrine Roulland, Paolo Vineis and Bertrand Nadel have contributed equally to this work. Electronic supplementary material The online version of this article (doi: 10.1007/s10552-015-0677-2) contains supplementary material, which is available to authorized users.
  • Identifier: ISSN: 0957-5243 ; E-ISSN: 1573-7225 ; DOI: 10.1007/s10552-015-0677-2