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Vitamin D supplementation improves waist-to-hip ratio and fasting blood glucose in vitamin D deficient, overweight or obese Asians: A pilot secondary analysis of a randomised controlled trial

Scott, David ; Mousa, Aya ; Naderpoor, Negar ; de Courten, Maximilian P.J ; Scragg, Robert ; de Courten, Barbora

The Journal of steroid biochemistry and molecular biology, 2019, Vol.186, p.136-141 [Peer Reviewed Journal]

England: Elsevier BV

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  • Title:
    Vitamin D supplementation improves waist-to-hip ratio and fasting blood glucose in vitamin D deficient, overweight or obese Asians: A pilot secondary analysis of a randomised controlled trial
  • Author/Creator: Scott, David ; Mousa, Aya ; Naderpoor, Negar ; de Courten, Maximilian P.J ; Scragg, Robert ; de Courten, Barbora
  • Publisher: England: Elsevier BV
  • Language: English
  • Subjects: Supplementation ; Glucose ; Vitamin D ; Insulin ; Asian ; Body composition
  • Is Part Of: The Journal of steroid biochemistry and molecular biology, 2019, Vol.186, p.136-141
  • Description: •We previously reported no effects of vitamin D supplements in overweight/obesity.•In a subset of Asians, vitamin D improved waist-hip ratio and fasting glucose.•Other markers of insulin sensitivity and body composition did not improve.•Vitamin D supplementation may be more effective in specific ethnic groups. Recent trials do not support a role for vitamin D supplementation in prevention or treatment of type 2 diabetes mellitus, although effects may differ in Asian populations. In this pilot secondary analysis of a placebo-controlled randomised trial of overweight or obese individuals with low 25-hydroxyvitamin D (25(OH)D < 50 nmol/L), we examined whether vitamin D supplementation improved insulin sensitivity or body composition in participants of Asian ethnicity. Amongst 65 trial participants, 33 reported being of Asian descent (mean ± SD age 30 ± 7 years; 67% male). Participants were block randomised to receive vitamin D (n = 14; initial bolus dose of 2500 μg cholecalciferol followed by 100 μg cholecalciferol/d) or placebo (n = 19; identical capsules) for 16 weeks. Primary outcome was change in insulin sensitivity (M-value) assessed by hyperinsulinemic-euglycemic clamp. Secondary outcomes were changes in 25(OH)D (chemiluminescent immunoassay), fasting blood glucose (YSI Stat 2300), and body composition including waist-hip ratio and total body fat percentage (dual-energy X-ray absorptiometry). Questionnaires assessed sun-exposure habits, physical activity, and diet. After the 16-week intervention, 25(OH)D concentrations increased significantly in the vitamin D group with no change in placebo (61.4 ± 21.1 vs −0.4 ± 12.7 nmol/L; P < 0.01). Vitamin D group participants demonstrated significant improvements in waist-hip ratio (-0.02 ± 0.03 vs 0.00 ± 0.02; P < 0.01) and fasting blood glucose (−0.1 ± 0.2 vs 0.2 ± 04 mmol/L; P < 0.04) compared with the placebo group, but changes in insulin sensitivity and other body composition measures did not differ significantly between groups (all P > 0.05). In conclusion, vitamin D supplementation improved waist-hip ratio and fasting blood glucose in overweight and obese Asian-Australians with low vitamin D concentrations. Further research is required to determine whether vitamin D supplementation is potentially more effective in specific ethnic groups.
  • Notes: 0960-0760
  • Identifier: ISSN: 0960-0760
    EISSN: 1879-1220
    DOI: 10.1016/j.jsbmb.2018.10.006
    PMID: 30321667