skip to main content
Resource type Show Results with: Show Results with: Index

Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3–6 years: follow-up of a randomized controlled trial

Trilok - Kumar, Geeta ; Kaur, Manpreet ; Rehman, Andrea M ; Arora, Harsh ; Rajput, Mohammad Muntafa ; Chugh, Reema ; Kurpad, Anura ; Sachdev, Harshpal Singh ; Filteau, Suzanne

International Journal of Epidemiology, 2015, Vol. 44(3), pp.894-905 [Peer Reviewed Journal]

Full text available online

Citations Cited by
  • Title:
    Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3–6 years: follow-up of a randomized controlled trial
  • Author/Creator: Trilok - Kumar, Geeta ; Kaur, Manpreet ; Rehman, Andrea M ; Arora, Harsh ; Rajput, Mohammad Muntafa ; Chugh, Reema ; Kurpad, Anura ; Sachdev, Harshpal Singh ; Filteau, Suzanne
  • Subjects: Vitamin D ; Bone Health ; Body Composition ; Motor Development ; Low Birth Weight
  • Is Part Of: International Journal of Epidemiology, 2015, Vol. 44(3), pp.894-905
  • Description: Background: The long-term effects of infant vitamin D supplementation and status are unclear since there have been few controlled intervention trials and these have been small and contradictory. The Delhi Infant Vitamin D Supplementation (DIVIDS) trial found that supplementation of low-birthweight term infants with one recommended dietary allowance of vitamin D from 1 week to 6 months of age resulted in increased length and weight at 6 months. In the DIVIDS-2 study we followed up the DIVIDS children, now aged 3–6 years, to determine longer-term effects. Methods: DIVIDS children, 446 from the vitamin D arm and 466 from the placebo arm, attended the follow-up visit. Data collection included anthropometry, blood pressure, bone structure and strength by quantitative ultrasound (QUS), gross motor tests, deuterium dilution test of body composition on a subset ( n  = 229) and blood samples for measurement of vitamin D status. Results: Body mass index Z scores (BMIZ) were lower (adjusted P = 0.003)in the vitamin D Group [−1.18 (SD 0.92)] when compared with the placebo [−1.02 (SD 0.91)] group as a result of slightly lower weight and slightly greater height. The vitamin D group also had lower thigh circumference and arm muscle area and borderline lower mid-upper arm circumference. There were no group differences in body fat percentage, bone QUS or blood pressure and few differences in motor development measures. Conclusions: Vitamin D supplementation of low-birthweight infants in infancy resulted in children being thinner at age 3–6 years but in no differences in functional outcomes.
  • Identifier: ISSN: 0300-5771 ; E-ISSN: 1464-3685 ; DOI: 10.1093/ije/dyv116