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Material Type: Article
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Disrupted-in-Schizophrenia-1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1—neuregulin cascadeSeshadri, Saurav ; Kamiya, Atsushi ; Yokota, Yukako ; Prikulis, Ingrid ; Kano, Shin-Ichi ; Hayashi-Takagi, Akiko ; Stanco, Amelia ; Eom, Tae-Yeon ; Rao, Sarada ; Ishizuka, Koko ; Wong, Philip ; Korth, Carsten ; Anton, E. S. ; Sawa, Akira ; Snyder, SolomonProceedings of the National Academy of Sciences of the United States of America, 23 March 2010, Vol.107(12), pp.5622-5627 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescenceHayashi-Takagi, Akiko ; Araki, Yoichi ; Nakamura, Mayumi ; Vollrath, Benedikt ; Duron, Sergio G. ; Yan, Zhen ; Kasai, Haruo ; Huganir, Richard L. ; Campbell, David A. ; Sawa, AkiraProceedings of the National Academy of Sciences of the United States of America, 29 April 2014, Vol.111(17), pp.6461-6466 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent mannerRamsey, Amy J. ; Milenkovic, Marija ; Oliveira, Ana F. ; Escobedo-Lozoya, Yasmin ; Seshadri, Saurav ; Salahpour, Ali ; Sawae, Akira ; Yasuda, Ryohei ; Caron, Marc G. ; Snyder, Solomon H.Proceedings of the National Academy of Sciences of the United States of America, 5 April 2011, Vol.108(14), pp.5795-5800 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illnessJohnson, Alexander W. ; Jaaro-Peled, Hanna ; Shahani, Neelam ; Sedlak, Thomas W. ; Zoubovsky, Sandra ; Burruss, Daniel ; Emiliani, Francesco ; Sawa, Akira ; Gallagher, MichelaProceedings of the National Academy of Sciences of the United States of America, 23 July 2013, Vol.110(30), pp.12462-12467 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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Two Genes Link Two Distinct PsychosesSawa, Akira ; Snyder, Solomon H.Science, 18 November 2005, Vol.310(5751), pp.1128-1129 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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Disrupted-in-Schizophrenia-1 (DISC-1): Mutant Truncation Prevents Binding to NudE-like (NUDEL) and Inhibits Neurite OutgrowthOzeki, Yuji ; Tomoda, Toshifumi ; Kleiderlein, John ; Kamiya, Atsushi ; Bord, Lyuda ; Fujii, Kumiko ; Okawa, Masako ; Yamada, Naoto ; Hatten, Mary E. ; Snyder, Solomon H. ; Ross, Christopher A. ; Sawa, AkiraProceedings of the National Academy of Sciences of the United States of America, 07 January 2003, Vol.100(1), pp.289-294 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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Schizophrenia: Diverse Approaches to a Complex DiseaseSawa, Akira ; Snyder, Solomon H.Science, 26 April 2002, Vol.296(5568), pp.692-695 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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Dominant-Negative DISC1 Transgenic Mice Display Schizophrenia-Associated Phenotypes Detected by Measures Translatable to HumansHikida, Takatoshi ; Jaaro-Peled, Hanna ; Seshadri, Saurav ; Oishi, Kenichi ; Hookway, Caroline ; Kong, Stephanie ; Wu, Di ; Xue, Rong ; Andradé, Manuella ; Tankou, Stephanie ; Mori, Susumu ; Gallagher, Michela ; Ishizuka, Koko ; Pletnikov, Mikhail ; Kida, Satoshi ; Sawa, AkiraProceedings of the National Academy of Sciences of the United States of America, 4 September 2007, Vol.104(36), pp.14501-14506 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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Elucidating The Pathogenesis Of Schizophrenia: Disc-1 Gene May Predispose To Neurodevelopmental Changes Underlying SchizophreniaSawa, AkiraBMJ: British Medical Journal, 20 September 2003, Vol.327(7416), pp.632-633 [Peer Reviewed Journal]Full text available online |
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Material Type: Article
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A Form of DISC1 Enriched in Nucleus: Altered Subcellular Distribution in Orbitofrontal Cortex in Psychosis and Substance/Alcohol AbuseSawamura, Naoya ; Sawamura-Yamamoto, Takako ; Ozeki, Yuji ; Ross, Christopher A. ; Sawa, Akira ; Snyder, Solomon H.Proceedings of the National Academy of Sciences of the United States of America, 25 January 2005, Vol.102(4), pp.1187-1192 [Peer Reviewed Journal]Full text available online |