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Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries

Craven, Philip ; Aimon, Anthony ; Dow, Mark ; Fleury-Bregeot, Nicolas ; Guilleux, Rachel ; Morgentin, Remy ; Roche, Didier ; Kalliokoski, Tuomo ; Foster, Richard ; Marsden, Stephen P ; Nelson, Adam

Bioorganic & Medicinal Chemistry, 01 June 2015, Vol.23(11), pp.2629-2635 [Peer Reviewed Journal]

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Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis

Frei, Michelle S ; Bilyard, Matthew K ; Alanine, Thomas A ; Galloway, Warren R.J.D ; Stokes, Jamie E ; Spring, David R

Bioorganic & Medicinal Chemistry, 01 June 2015, Vol.23(11), pp.2666-2679 [Peer Reviewed Journal]

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Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries

Colomer, Ignacio ; Adeniji, Ololade ; Burslem, George M ; Craven, Philip ; Rasmussen, Martin Ohsten ; Willaume, Anthony ; Kalliokoski, Tuomo ; Foster, Richard ; Marsden, Stephen P ; Nelson, Adam

Bioorganic & Medicinal Chemistry, 01 June 2015, Vol.23(11), pp.2736-2740 [Peer Reviewed Journal]

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Exploiting the human peptidome for novel antimicrobial and anticancer agents

Bosso, Matteo ; Ständker, Ludger ; Kirchhoff, Frank ; Münch, Jan

Bioorganic & Medicinal Chemistry, 01 June 2018, Vol.26(10), pp.2719-2726 [Peer Reviewed Journal]

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Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet–Spengler cyclization/metal-catalyzed cross coupling/amidation sequence

Petersen, Rico ; Cohrt, A. Emil ; Petersen, Michael Åxman ; Wu, Peng ; Clausen, Mads H ; Nielsen, Thomas E

Bioorganic & Medicinal Chemistry, 01 June 2015, Vol.23(11), pp.2646-2649 [Peer Reviewed Journal]

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Branching cascades provide access to two amino-oxazoline compound libraries

Murali, Annamalai ; Medda, Federico ; Winkler, Matthias ; Giordanetto, Fabrizio ; Kumar, Kamal

Bioorganic & Medicinal Chemistry, 01 June 2015, Vol.23(11), pp.2656-2665 [Peer Reviewed Journal]

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Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory

Narhe, Bharat D ; Breman, Arjen C ; Padwal, Jalindar ; Vandenput, Dirk A.L ; Scheidt, Joeri M ; Benningshof, Jorg C.J ; van Der Marel, Gijsbert A ; Overkleeft, Herman S ; van Der Stelt, Mario ; Filippov, Dmitri V

Bioorganic & Medicinal Chemistry, 01 October 2017, Vol.25(19), pp.5160-5170 [Peer Reviewed Journal]

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Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach

Jüse, Ulrike ; Arntzen, Magnus ; Højrup, Peter ; Fleckenstein, Burkhard ; Sollid, Ludvig M

Bioorganic & Medicinal Chemistry, 2011, Vol.19(7), pp.2470-2477 [Peer Reviewed Journal]

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Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin

Dyson, Lauren ; Wright, Anthony D ; Young, Kelly A ; Sakoff, Jennette A ; Mccluskey, Adam

Bioorganic & Medicinal Chemistry, 01 March 2014, Vol.22(5), pp.1690-1699 [Peer Reviewed Journal]

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Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

Kollmann, Christopher S ; Bai, Xiaopeng ; Tsai, Ching-Hsuan ; Yang, Hongfang ; Lind, Kenneth E ; Skinner, Steven R ; Zhu, Zhengrong ; Israel, David I ; Cuozzo, John W ; Morgan, Barry A ; Yuki, Koichi ; Xie, Can ; Springer, Timothy A ; Shimaoka, Motomu ; Evindar, Ghotas

Bioorganic & Medicinal Chemistry, 01 April 2014, Vol.22(7), pp.2353-2365 [Peer Reviewed Journal]

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Unbiased binding assays for discovering small-molecule probes and drugs

Kemp, Melissa M ; Weïwer, Michel ; Koehler, Angela N

Bioorganic & Medicinal Chemistry, 15 March 2012, Vol.20(6), pp.1979-1989 [Peer Reviewed Journal]

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In-cell production of a genetically-encoded library based on the θ-defensin RTD-1 using a bacterial expression system

Bi, Tao ; Li, Yilong ; Shekhtman, Alexander ; Camarero, Julio A

Bioorganic & Medicinal Chemistry, 15 March 2018, Vol.26(6), pp.1212-1219 [Peer Reviewed Journal]

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Allosteric inhibitors of Coxsackie virus A24 RNA polymerase

Schein, Catherine H ; Rowold, Diane ; Choi, Kyung H

Bioorganic & Medicinal Chemistry, 15 February 2016, Vol.24(4), pp.570-577 [Peer Reviewed Journal]

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On-bead cyclization in a combinatorial library of 15,625 octapeptides

Fluxa, Viviana S ; Reymond, Jean-Louis

Bioorganic & Medicinal Chemistry, 2009, Vol.17(3), pp.1018-1025 [Peer Reviewed Journal]

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15
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Design and synthesis of an optimized positional scanning library of peptoids: identification of novel multidrug resistance reversal agents

Masip, Isabel ; Cortés, Nuria ; Abad, Maria-José ; Guardiola, Marisa ; Pérez-Payá, Enrique ; Ferragut, José ; Ferrer-Montiel, Antonio ; Messeguer, Angel

Bioorganic & Medicinal Chemistry, 2005, Vol.13(6), pp.1923-1929 [Peer Reviewed Journal]

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Identification, structure–activity relationships and molecular modeling of potent triamine and piperazine opioid ligands

Yongye, Austin B ; Appel, Jon R ; Giulianotti, Marc A ; Dooley, Colette T ; Medina-Franco, Jose L ; Nefzi, Adel ; Houghten, Richard A ; Martínez-Mayorga, Karina

Bioorganic & Medicinal Chemistry, 2009, Vol.17(15), pp.5583-5597 [Peer Reviewed Journal]

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17
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Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis

Martínez-Mayorga, Karina ; Medina-Franco, Jose L ; Giulianotti, Marc A ; Pinilla, Clemencia ; Dooley, Colette T ; Appel, Jon R ; Houghten, Richard A

Bioorganic & Medicinal Chemistry, 2008, Vol.16(11), pp.5932-5938 [Peer Reviewed Journal]

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18
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‘Mutational SURF’: A strategy for improving lead compounds identified from combinatorial libraries

Freier, Susan M ; Konings, Danielle A.M ; Wyatt, Jacqueline R ; Ecker, David J

Bioorganic & Medicinal Chemistry, 1996, Vol.4(5), pp.717-725 [Peer Reviewed Journal]

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19
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Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2

Jiang, Yu Lin ; Chung, Suhman ; Krosky, Daniel J ; Stivers, James T

Bioorganic & Medicinal Chemistry, 2006, Vol.14(16), pp.5666-5672 [Peer Reviewed Journal]

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Tetrabutylammonium fluoride-assisted rapid N 9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ

Brik, Ashraf ; Wu, Chung-Yi ; Best, Michael D ; Wong, Chi-Huey

Bioorganic & Medicinal Chemistry, 2005, Vol.13(15), pp.4622-4626 [Peer Reviewed Journal]

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